A proof of the unity, integrity and autopoietic autonomy of the whole human genome

  • Jean-claude PEREZ


Global analysis of 3 human genomes of increasing levels of evolution (Neanderthal / Sapiens Build34 / Sapiens hg38) reveals 2 levels of numerical constraints controlling, structuring and optimizing these genome's DNA sequences. A global constraint - called "HGO" for "Human Genome Optimum" - optimizes the genome at its global scale. The same operator applied to each of the 24 individual chromosomes reveals a hierarchical structure of these 24 chromosomes. Then analysing the single strand DNA CG / TA proportions at whole chromosomes and genome scale reveals strong fine-tuned numerical ratios evidencing the "closure" nature (Varela's autopoiesis theory) of whole human genome.


[1] Jun Wu et al, (2016), In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration, Nature (16 November 2016) | doi:10.1038/nature20565
[2] Lieberman-Aiden et al. (2009), Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science, 2009; DOI: 10.1126/science.1181369 .
[3] Perez JC (1991) Chaos DNA and neuro-computers: a golden link. Speculations in Science and Technology 14: 336-346.
[4] Marcer PJ (1992) Order and chaos in DNA – the Denis Guichard Prizewinner: Jean-Claude Perez. Kybernetes 21: 60-61.
[5] Perez JC (1997) L'adn Décrypté. Resurgence publisher Liege, Belgium.
[6] Perez JC (2009) Codex Biogenesis. Resurgence, Liege Belgium.
[7] Perez JC (2017) Sapiens Mitochondrial DNA Genome Circular Long Range Numerical Meta Structures are Highly Correlated with Cancers and Genetic Diseases mtDNA Mutations. J Cancer Sci Ther 9:512-527. doi: 10.4172/1948-5956.1000469 https://www.omicsonline.org/open-access/sapiens-mitochondrial-dna-genome-circular-long-range-numericalmeta-structures-are-highly-correlated-with-cancers-and-genetic-disea-1948-5956-1000469.php?aid=90737
[8] perez, DUF1220 Homo Sapiens and Neanderthal fractal periods architectures breakthrough(2017)SDRP Journal of Cellular and Molecular Physiology 1(1)
http://www.siftdesk.org/article-details/DUF1220 20Homo 20Sapiens 20and 20Neanderthal 20 20fractal 20periods 20architectures 20breakthrough/184?
[9] Perez J.C., (2017) "Global and long range fractal differences between sapiens and neanderthal genomes" , to be published in 2017.
[10] Perez JC (2010) Codon Populations in Single-Stranded Whole Human Genome DNA Are Fractal and Fine-Tuned by the Golden Ratio 1.618. Interdisciplinary Sciences: Computational Life Sciences 2: 1-13.
[11] Perez JC (2011) Caminos Interdisciplinaios. Seminario CLAVE_INTER, Espacio Interdisciplinario, Universidad de la Republica Montevideo, Uruguay.
[12] Perez JC (2011) Decoding Non-Coding DNA Codes: Human Genome Meta-Chromosomes Architecture. BIT Life Sciences’ 3rd Annual World Vaccine Congress, Beijing, China.
[13] Perez JC (2013) The “3 Genomic Numbers” Discovery: How Our Genome Single-Stranded DNA Sequence Is “Self-Designed” as a Numerical Whole. Applied Mathematics 4: 37-53.
[14] Perez J (2015) Deciphering Hidden DNA Meta-Codes -The Great Unification & Master Code of Biology. J Glycomics Lipidomics 5:131. doi: 10.4172/2153-0637.1000131
[15] Perez J.C, Fractal Self-similarity, Scale Invariance and Stationary waves Codes Architecture Human Chromosomes DNA sequences, (submitted journal « chaos, fractals and solitons », https://www.journals.elsevier.com/chaos-solitons-and-fractals/ ).
[16] Neanderthal genome (2014) http://www.nature.com/nature/journal/v505/n7481/full/nature12886.html
[17] Sapiens Build34 (2003) genome
[18] Sapiens HG38 (2013) genome https://www.ncbi.nlm.nih.gov/grc/human
[19] perez J.C., (2017), Symmetry and Asymmetry in the MENDELEEV’s Periodic Table Predictive EQUATION(2017)SDRP Journal of Computational Chemistry & Molecular Modelling 2(1)
http://www.siftdesk.org/article-details/Symmetry 20and 20Asymmetry 20in 20the 20MENDELEEV E2 80 99s 20Periodic 20Table 20Predictive 20EQUATION/224
[20] Friedman R, Cross M (2013) The Golden Ratio & Fibonacci Sequence: Golden Keys to Your Genius, Health, Wealth & Excellence. 1st (Edn), Hoshin Media, USA.
[21] Pellionisz AJ, Graham R, Pellionisz PA, Perez JC (2012) Recursive Genome Function of the Cerebellum: Geometric Unification of Neuroscience and Genomics. In: Manto M, DL, et al. (Eds) Handbook of the Cerebellum and Cerebellar Disorders. 1st (Edn), Springer, USA.
[22] Rapoport DL (2015) Möbius strip and Klein Bottle Genomic Topologies, Self reference, Harmonics and Evolution, Life.
http://www.quantumbiosystems.org/admin/files/QBS%202016.%207.%20107-173.pdf and https://www.academia.edu/30518156/Klein Bottle Logophysics Self-reference Heterarchies Genomic Topologies Harmonics and Evolution. Part III The Klein Bottle Logic of Genomics and its Dynamics Quantum Information Complexity and Palindromic Repeats in Evolution
[23] Montagnier L. et al, (2017) Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields, Water 2017, 9(5), 339 ; doi:10.3390/w9050339 http://www.mdpi.com/2073-4441/9/5/339/pdf
[24] Persaud, Dharam and O'Leary, James P., (2015) "Fibonacci Series, Golden Proportions, and the Human Biology" HWCOM Faculty Publications. Paper 27. http://digitalcommons.fiu.edu/com_facpub/27
Roman V Yampolskiy, (2017) On the origin of synthetic life: attribution of output to a particular algorithm,
[25] The Royal Swedish Academy of Sciences, Phys. Scr. 92 (2017), DOI : 10.1088/0031-8949/92/1/013002
[26] Perez J.C., (2017) "Humans and Primates Chromosomes4 Fractal CODES : periodic stationnary waveforms charaterizing and differenciating Neanderthal and Sapiens whole chromosomes DNA sequences" , (paper to be published, 2017).
[27] Perez, J.C., Decyphering “the MASTER CODE ®” Structure and Discovery of a Periodic Invariant Unifying 160 HIV1/HIV2/SIV Isolates Genomes. Biomed J Sci & Tech Res 1(2)-2017. BJSTR. MS.ID.000209. http://biomedres.us/pdfs/BJSTR.MS.ID.000209.pdf
[28] Varela F. J. (1981) Autonomy and autopoiesis. In: Roth G. & Schwegler H. (eds.) Self-organizing systems: An interdiciplinary approach. Campus Verlag, Frankfurt/New York: 14–24. Available at http://cepa.info/2063
[29] H.R. Maturana; F.J. Varela (1980). "The cognitive process". Autopoiesis and cognition: The realization of the living. Springer Science & Business Media. p. 13. ISBN 978-90-277-1016-1.
[30] Kellie A Schaefer et al.,(2017) Unexpected mutations after CRISPR-Cas9 editing in vivo, Nature Methods (2017). Nature Methods 14, 547–548 (2017) doi:10.1038/nmeth.4293 Published online 30 May 2017
[31] Perez JC (2017) The “Master Code of DNA”: Towards the Discovery of the SNPs Function (Single-Nucleotide Polymorphism). J Clin Epigenet. Vol. 3 No. 3:26 http://clinical-epigenetics.imedpub.com/the-master-code-of-dna-towards-the-discovery-of-the-snps-function-singlenucleotide-polymorphism.pdf
[32] Perez, J.C. (2017), The “Master Code of Biology”: Self-assembly of two identical Peptides beta A4 1-43 "Amyloid" in Alzheimer’s Diseases. Biomed J Sci & Tech Res 1(4)-2017.
[33] Perez, J.C. (2017), The «Master Code of Biology»: from Prions and Prions-like Invariants to the Self-assembly Thesis. Biomed J Sci & Tech Res 1(4)-2017.
[34] Perez, J.C., (2017) The «Human Genome Optimum» (HGO): Towards a Universal Law controlling all Human Cancer Chromosome LOH Deletions (Loss of Heterozygosity), Global Journal of Medical Research , GJMR Volume 17 Issue 6 Version 1.0
How to Cite
PEREZ, Jean-claude. A proof of the unity, integrity and autopoietic autonomy of the whole human genome. Research in Biological Chemistry, [S.l.], v. 1, n. 1, p. 1-10, nov. 2017. Available at: <https://www.rbchemistry.com/index.php/rbc/article/view/2>. Date accessed: 25 june 2019.

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